Jacques Jean-François
Professeur adjoint

Recherche


Mes intérêts en recherche portent sur 2 axes principaux 

1- La conception ou la mise au point de systèmes macro ou micro- polymériques susceptibles de stabiliser et d’améliorer la performance in vivo de biomolécules d’intérêt biologique ou thérapeutique (enzymes, anticorps monoclonaux, peptides).

2-Comprendre  l’influence du système immunitaire sur la performance de ces systèmes macro ou micro-polymériques in vivo. L’accent est porté sur le rôle du macrophage une des composantes majeures de la réponse immune.

 

Publications

P. He, J. Jean-Francois and G. Fortier. Synthesis and in vitro characterization of Poly(ethylene glycol)-albumin hydrogel micropartcles. To be submitted pending patent submission.

J. Jean-Francois, Y. Liu and G. Fortier. Hydrogel microparticles of PEG-albumin: Influence of size and surface nature on their biodistribution and elimination in rat.  To be submitted pending patent submission.

J. Jean-Francois and G. Fortier. Cellular and biochemical short-term responses to RSA-PEG hydrogel microparticles injected in rat peritoneum. To be submitted pending patent submission.

J. Jean-Francois and G. Fortier. Instillation of RSA-PEG hydrogel microparticles in lungs of normal and diabetic rats. To be submitted pending patent submission.

J. Jean-Francois, E.M. D Urso and G. Fortier (1997) Immobilization of L-asparaginase into a biocompatible poly(ethylene glycol)-albumin hydrogel: II. Evaluation of the in vivo performances. Biotechnol. Appl. Biochem. 26, 203-212.

J. Jean-Francois and G. Fortier (1996) Immobilization of L-asparaginase into a biocompatible poly(ethylene glycol)-albumin hydrogel. I. Preparation and in vitro characterization. Biotechnol. Appl. Biochem. 23, 221-226.

G. Fortier, N. Demers, J. Jean-Francois, J.C. Gayet and E.M. D Urso. Poly(ethylene glycol) crosslinked to albumin as a support for enzyme immobilization. In Methods in Biotechnology. Vol. 1: Immobilization of enzymes and cells. G.F. Bickerstaff, Ed. Humana Press, Totowa, New Jersey, 1997, Chapter 15, 177-123.

E.M. D Urso, J. Jean-Francois and G. Fortier: Bioapplication of poly(ethylene glycol)-albumin hydrogels: Matrix for enzyme immobilization. In Hydrogel and Biodegradable Polymers for Bioapplications. ACS Symposium Series no 627. R. Ottenbrite, S. Huang and K. Park, Eds. 1996, Washington, Chapter 4, 25-41.

E.M. D Urso, J.C. Doillon, J. Jean-Francois and G. Fortier (1995) Poly(ethylene glycol)- serum albumin hydrogel as a new matrix for enzyme immobilization: Biomedical applications. J. Artif. Cells, Blood Subst. and Immobilization Biotechnol. 23, 587-595.